产品货号：
Z11983
中文名称：
BORA抗体
英文名称：
Anti-BORA Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-BORA Antibody |
| 指标别名 | BORA,C13orf34,HsBora,Protein aurora borealis |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | BORA |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Bora antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human Bora.The immunogen is located within amino acids 410 - 460 of Bora. |
| 计算分子量 | 61kDa |
| 成分 | Bora Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | Bora Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Bora (Protein aurora borealis) is a key activator of Aurora Related Protein Kinase A (ARK-1),which is a centrosome-associated serine/threonine kinase that regulates centrosome maturation,bipolar spindle assembly and chromosome segregation during mitosis.Bora is localized to the nucleus until mitosis is initiated,then translocates to the cytoplasm in a Cdc2 dependent manner.Activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate ARK-1.PLK1 (polo-like kinase-1) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation by ARK-1.Bora and ARK-1 cooperatively activate PLK1 and control mitotic entry.Bora mutants result in multipolar spindles in mitosis identical to those observed when ARK-1 function is blocked.Thus,the ARK1-Bora-PLK1 regulatory circuit in mammalian cells elucidates a key mechanism in cell cycle regulation.At least three isoforms of Bora are known to exist. |
| Uniprot ID | Q6PGQ7 |
| 基因名全称 | Bora,aurora kinase A activator |
| 蛋白名全称 | Bora,aurora kinase A activator |
| 推荐稀释比 | Bora antibody can be used for detection of Bora by Western blot at 1～2μg/mL.Antibody can also be used for immunohistochemistry starting at 2.5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in mouse samples;Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples.All other applications and species not yet tested. |
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